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Rutaecarpine has long been used in traditional Chinese medicine to counteract the effects of caffeine, aid digestion problems, counter infection and maintain body weight.

It is a plant native to China and Korea that grows berries known as "fruits of evodia," or evodia fructae. Rutaecarpine is a compound that is isolated from the berries produced by the evodia rutaecarpa plant.

Other Names for Rutaecarpine

Rutaecarpine is also referred to as evodia, evodia extract, evodiae fructus, evodia fruit, and evodia rutaecarpa.

Rutaecarpine Benefits

While the research on the effects of rutaecarpine on the human body is still somewhat limited, it is suggested that the chemical has a number of potential benefits, including the following:

Weakens the effects of caffeine. Rutaecarpine has been shown to metabolize caffeine, causing it to be excreted from the body quickly and reducing its effects on the body1. With quick elimination of caffeine, any unpleasant side effects of caffeine can subside, including sleeplessness and jitters.

May help kill off cancer cells. Some studies2 suggest that rutaecarpine shows promise as an anti-cancer agent by killing cancer cells and inhibiting the growth of tumor cell lines, particularly for cervical cancer, melanoma and cancer of the thyroid3.

Reduces inflammation. Rutaecarpine has long been used for its anti-inflammatory properties thanks to the actions of certain constituents of the evodia rutaecarpa plant4.

May burn body fat. Rutaecarpine has been investigated as a fat burner5 and therefore has been touted as a potentially effective weight loss agent. in animal studies, it appears to make subjects feel hotter and expends heat more efficiently, which has a fat-burning effect.

Other potential benefits of rutaecarpine may include the following, though evidence to support such claims is very limited:

  • Diarrhea
  • Nausea
  • Vomiting
  • Lack of Menstruation
  • Stomach Ulcers
  • Gastroesophageal Reflux Disease
  • Fluid Retention


Recommended Dosage of Rutaecarpine

Currently, there isn't enough scientific data on rutaecarpine to determine an appropriate dose for the chemical. That said, dosing should be based on a number of factors including the user's:

  • Age
  • Weight
  • Health
  • Use of Medications
  • Presence of Illness

It's also important to follow manufacturers' suggestions when dosing, so be sure to follow specific directions on product labels and always consult with a doctor or pharmacist before using rutaecarpine or any other natural supplement.

Supplementing With Rutaecarpine

Certain individuals should not take rutaecarpine, including pregnant or breastfeeding women, as there is insufficient information showing whether or not the chemical is safe for both mother and baby.

Further, those who are scheduled for surgery in the near future should not take rutaecarpine because of its link to slowed blood clotting. There may be a concern that rutaecarpine could increase the risk of bleeding during and after surgery.

Interactions With Medications

Caution should be taken when using rutaecarpine while taking other medications as the chemical may interact with them and reduce their effect, such as blood clotting medication. It's important to speak with a healthcare provider before introducing rutaecarpine to the body when in the presence of other medications.

Is Rutaecarpine Healthy?

There may be some evidence to suggest that rutaecarpine can help reduce the jittery effects of caffeine, help with weight loss, and aid with digestive issues. But the science behind the chemical is limited to just animal studies.

More human studies are needed to solidify rutaecarpine benefits on the human body. As with any other supplement or herbal product, it's important to consult with a physician or health care practitioner first.

Rutaercarpine Supplementation With Total Sleep

There are always certain instances where diet is not going to give you everything you need. There's no need to worry if your diet does not provide the necessary amount of rutaercarpine. Oral supplements are available for those who want to make sure they are consuming enough in their daily diet.

Total Sleep is a powerful, all-natural supplement that contains clinically-proven dosages of rutaercarpine, lemon balm extract and other herbs and nutrients. Total Sleep is specially designed to help you sleep naturally. Learn more about Total Sleep and UMZU's line of natural supplements by visiting our online showroom.

With crazy, busy schedules it is easy to be tempted by fast food, processed food, and an abundance of poor eating choices. With obesity and bad eating habits on the rise, it's more important now than ever to pay attention to what you put in your body. Your health is one of the most important investments you can make. After all, you will need it for years to come! Take care to make sure you are receiving adequate amounts of both macronutrients and micronutrients, as well as engaging in healthy exercise. Begin your journey to a healthier you today!

Citations and Sources

Noh K, Seo Y, Lee S, et al. Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats. Arch Pharm Res. 2011;34(1):119-125.
Zhang Y, Wu L, Tashiro S, Onodera S, Ikejima T. Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis. Acta Pharmacol Sin. 2004;25(1):83-89.
Chen M, Yu C, Wang S, et al. Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO. J Cell Biochem. 2010;110(6):1495-1503.
Choi Y, Shin E, Kim Y, Cai X, Lee J, Kim H. Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. Arch Pharm Res. 2006;29(4):293-297.
Bak E, Park H, Kim J, Kim J, Yoo Y, Cha J. Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes. Int J Obes (Lond). 2010;34(2):250-260.
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